​Treatment of Diabetes with a Medicinal Plant “Citrullus colocynthis” in Wistar Rats

Background: Citrullus colocynthis is a plant of the Cucurbitaceous family, native to arid soils. Coloquine common in humid and moderately dry tropical regions Algeria. The present study aims evaluate vitro anti-free radical activity C. fruit extract on diabetic rats by evaluation impact these extracts eight (08) blood parameters. Methods: Following daily intraperitoneal injection 1 ml Alloxan healthy Wistar Albinos (diabetes induction), 20 mg/kgp.c cucurbitacin glycosides was carried out. treatment effect monitored assessment Result: Intraperitoneal mg/kg cucurbitacins exhibited significant antidiabetic, anti-hyperureimia, anti-proteinemia, anti-hyperlipidemia anti-hypercholesterolemia induced laboratory rats. These also showed improvement lipid, protein, creatinine urea profile. In perspective more thorough investigations are required unravel process behind direct control type II diabetes.